Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 530932
Title A saturated fatty acid rich diet can induce an 'obese-like' gene expression profile in adipose tissue
Author(s) Dijk, Susan van; Feskens, Edith; Bos, M.B.; Hoelen, Dianne W.; Heijligenberg, Rik; Grootte Bromhaar, Mechteld; Groot, Lisette de; Vries, Jeanne de; Muller, Michael; Afman, Lydia
Department(s) Human Nutrition (HNE)
Chair Nutrition and Health over the Lifecourse
Publication type Dataset
Publication year 2010
Keyword(s) GSE14954 - Homo sapiens - PRJNA111821
Abstract We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a SFA-rich or a MUFA-rich diet for 8 weeks. Subcutaneous adipose tissue samples were obtained and insulin sensitivity was measured. Whole genome micro-array analysis was performed on the adipose tissue samples. Consumption of a SFA-rich diet resulted in a pro-inflammatory 'obese-like' gene expression profile while consumption of a MUFA-rich diet caused a more anti-inflammatory profile. This suggests that replacement of dietary SFA by MUFA could prevent adipose tissue inflammation and may reduce the risk for inflammation related diseases such as the metabolic syndrome.
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