Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 530934
Title Mucosal responses of healthy humans to three different probiotic Lactobacillus bacteria
Author(s) Baarlen, Peter van; Kleerebezem, Michiel; Brummer, Robert-Jan M.; Meer, Cindy van der; Hooiveld, Guido; Troost, Fred J.; Boekschoten, Mark
Department(s) Host Microbe Interactomics
Microbiological Laboratory
Human Nutrition (HNE)
Publication type Dataset
Publication year 2010
Keyword(s) GSE18741 - Homo sapiens - PRJNA121653
Abstract Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function via largely unknown molecular mechanisms. To explore in vivo mucosal responses of healthy adults to probiotics, we obtained transcriptomes in an intervention study following a double-blind placebo-controlled cross-over design. In the mucosa of the proximal small intestine of healthy volunteers, probiotic strains from the species Lactobacillus acidophilus, L. casei and L. rhamnosus each induced differential gene regulatory networks and pathways in the human mucosa. Comprehensive analyses revealed that these transcriptional networks regulate major basal mucosal processes, and uncovered remarkable similarity to response profiles obtained for specific bioactive molecules and drugs. This study elucidates how intestinal mucosa of healthy humans perceive different probiotics and provides avenues for rationally designed tests of clinical applications.
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