Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 531369
Title A novel hybrid kinase is essential for regulating the σB-mediated stress response of Bacillus cereus.
Author(s) Been, M.W.H.J. de; Tempelaars, Marcel; Schaik, W. van; Moezelaar, Roy; Siezen, R.J.; Abee, Tjakko
Department(s) Food Microbiology Laboratory
FBR Food Technology
VLAG
Publication type Dataset
Publication year 2009
Keyword(s) GSE14589 - Bacillus cereus - PRJNA111709 - Bacillus cereus ATCC 14579
Abstract A common bacterial strategy for monitoring environmental challenges is to use two-component systems, which consist of a sensor histidine kinase (HK) and a response regulator (RR). In the food-borne pathogen Bacillus cereus, the alternative sigma factor σB is activated by the RR RsbY. Here we present strong indications that the PP2C-type phosphatase RsbY receives its input from the multi-sensor hybrid kinase BC1008 (renamed RsbK). Genome analyses revealed that, across bacilli, rsbY and rsbK are located in a conserved gene cluster. A B. cereus rsbK deletion strain was shown to be incapable of inducing σB upon stress conditions and was impaired in its heat adaptive response. Comparison of the wild-type and rsbK mutant transcriptomes upon heat shock revealed that RsbK was primarily involved in the activation of the σB-mediated stress response. Truncation of the RsbK RR receiver domain demonstrated the importance of
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