Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 531396
Title Innate Immune Recognition of Bacterial Viability Instructs Human T follicular Helper Cell Differentiation
Author(s) Valai, Atijeh; Ugolini, Matteo; Gerhard, Jenny; Georg, Philipp; Helbig, Elisa T.; Opitz, Bastian; Kurth, Florian; Boekschoten, Mark; Muller, Michael; Suttorp, Norbert; Sander, Leif E.
Department(s) VLAG
Chair Nutrition Metabolism and Genomics
Human Nutrition (HNE)
Publication type Dataset
Publication year 2016
Keyword(s) GSE68255 - Homo sapiens - PRJNA282140
Abstract Live attenuated vaccines are often superior to dead vaccines, yet the immunological mechanisms remain largely obscure. We have recently uncovered an inherent capacity of antigen-presenting cells (APC) to discriminate live from killed bacteria by virtue of vita-PAMPs. Here we found that innate recognition of bacterial viability strongly promotes the differentiation of fully functional T follicular helper (TFH) cells. We identify TLR8 and its signaling adaptor MyD88 as critical sensor for bacterial viability in human APC, activation of which is required and sufficient to induce selective transcriptional remodeling and the production of TFH promoting signals like IL-12. Activators of other TLRs including licensed vaccine adjuvants fail to do so. Consequently, vita-PAMP receptors such as TLR8 represent promising targets for adjuvants to improve the efficacy of modern inanimate subunit vaccines.
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