Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 532073
Title Host miRNAs are involved in hormonal regulation of HaSNPV-triggered climbing behaviour in Helicoverpa armigera
Author(s) Zhang, Songdou; An, Shiheng; Hoover, Kelli; Li, Zhen; Li, Xiangrui; Liu, Xiaoming; Shen, Zhongjian; Fang, Haibo; Ros, Vera I.D.; Zhang, Qingwen; Liu, Xiaoxia
Source Molecular Ecology 27 (2018)2. - ISSN 0962-1083 - p. 459 - 475.
Department(s) Laboratory of Virology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Helicoverpa armigera - 20-hydroxyecdysone - Baculovirus - Climbing behaviour - Juvenile hormone - MiRNAs
Abstract Baculoviruses manipulate host climbing behaviour to ensure that the hosts die at elevated positions on host plants to facilitate virus proliferation and transmission, which is a process referred to as tree-top disease. However, the detailed molecular mechanism underlying tree-top disease has not been elucidated. Using transcriptome analysis, we showed that two hormone signals, juvenile hormone (JH) and 20-hydroxyecdysone (20E), are key components involved in HaSNPV-induced tree-top disease in Helicoverpa armigera larvae. RNAi-mediated knockdown and exogenous hormone treatment assays demonstrated that 20E inhibits virus-induced tree-top disease, while JH mediates tree-top disease behaviour. Knockdown of BrZ2, a downstream signal of JH and 20E, promoted HaSNPV-induced tree-top disease. We also found that two miRNAs target BrZ2 and are involved in the cross-talk regulation between 20E and JH manipulating HaSNPV replication, time to death and HaSNPV-induced tree-top disease.
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