Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 533480
Title Regulation of three virulence strategies of Mycobacterium tuberculosis : A success story
Author(s) Zondervan, Niels A.; Dam, Jesse C.J. Van; Schaap, Peter J.; Martins dos Santos, Vitor A.P.; Suarez-Diez, Maria
Source International Journal of Molecular Sciences 19 (2018)2. - ISSN 1661-6596
DOI http://dx.doi.org/10.3390/ijms19020347
Department(s) Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) CAMP - Divalent metal - Dormancy - Escape - Esx - Immune modulation - Iron - Manganese - Mycobacteria - Phagosome rupture - Pore - Virulence - Zinc
Abstract Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome.
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