Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 533979
Title Water-soluble chitosan derivatives and pH-responsive hydrogels by selective C-6 oxidation mediated by TEMPO-laccase redox system
Author(s) Botelho da Silva, Suse; Krolicka, Malgorzata; Broek, Lambertus A.M. van den; Frissen, August E.; Boeriu, Carmen Gabriela
Source Carbohydrate Polymers 186 (2018). - ISSN 0144-8617 - p. 299 - 309.
Department(s) Bioprocess Engineering
FBR BP Biorefinery & Sustainable Value Chains
FBR Sustainable Chemistry & Technology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) 2,2,6,6-Tetramethylpiperidinoxyl radical (TEMPO) - Chitosan - Laccase - Oxidation - pH-responsive hydrogel - Soluble chitosan
Abstract Chitosan is a polysaccharide with recognized antioxidant, antimicrobial and wound healing activities. However, this polymer is soluble only in dilute acidic solutions, which restricts much of its applications. A usual strategy for improving the functionality of polysaccharides is the selective oxidation mediated by 2,2,6,6-tetra-methyl-1-piperidinidyloxy (TEMPO) using laccase as a co-oxidant. In this work, the TEMPO-laccase redox system was used for the first time to selectively oxidize chitosan in order to produce tailored derivatives. The reaction was performed at pH 4.5 under continuous air supply and the oxidized products were characterized structurally and functionally. The TEMPO-laccase oxidation successfully added aldehyde and carboxylate groups to chitosan structure resulting in derivatives with oxidation between 4 and 7%. These derivatives showed increased solubility and decreased viscosity in solution. If chitosan is dissolved in diluted hydrochloric acid prior to TEMPO-laccase oxidation, a crosslinked chitosan derivative was produced, which was able to form a pH-responsive hydrogel.
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