Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 534579
Title Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis : A meta-analysis of individual patient data from cohorts within the CHANCES consortium
Author(s) Ordóñez-Mena, J.M.; Walter, V.; Schöttker, B.; Jenab, M.; O'Doherty, M.G.; Kee, F.; Bueno-de-Mesquita, B.; Peeters, P.H.M.; Stricker, B.H.; Ruiter, R.; Hofman, A.; Söderberg, S.; Jousilahti, P.; Kuulasmaa, K.; Freedman, N.D.; Wilsgaard, T.; Wolk, A.; Nilsson, L.M.; Tjønneland, A.; Quirós, J.R.; Duijnhoven, F.J.B. van; Siersema, P.D.; Boffetta, P.; Trichopoulou, A.; Brenner, H.
Source Annals of Oncology 29 (2018)2. - ISSN 0923-7534 - p. 472 - 483.
DOI http://dx.doi.org/10.1093/annonc/mdx761
Department(s) Cultural Geography
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Colorectal neoplasms - Meta-analysis - Smoking - Smoking cessation - Survival
Abstract Background: Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies and might also be associated with prognosis after CRC diagnosis. However, current evidence on smoking in association with CRC prognosis is limited. Patients and methods: For this individual patient data meta-analysis, sociodemographic and smoking behavior information of 12 414 incident CRC patients (median age at diagnosis: 64.3 years), recruited within 14 prospective cohort studies among previously cancer-free adults, was collected at baseline and harmonized across studies. Vital status and causes of death were collected for a mean follow-up time of 5.1 years following cancer diagnosis. Associations of smoking behavior with overall and CRC-specific survival were evaluated using Cox regression and standard meta-analysis methodology. Results: A total of 5229 participants died, 3194 from CRC. Cox regression revealed significant associations between former [hazard ratio (HR)=1.12; 95 % confidence interval (CI)=1.04-1.20] and current smoking (HR=1.29; 95% CI=1.04-1.60) and poorer overall survival compared with never smoking. Compared with current smoking, smoking cessation was associated with improved overall (HR<10 years=0.78; 95% CI=0.69-0.88; HR≥10 years=0.78; 95% CI=0.63-0.97) and CRC-specific survival (HR≥10 years=0.76; 95% CI=0.67-0.85). Conclusion: In this large meta-analysis including primary data of incident CRC patients from 14 prospective cohort studies on the association between smoking and CRC prognosis, former and current smoking were associated with poorer CRC prognosis compared with never smoking. Smoking cessation was associated with improved survival when compared with current smokers. Future studies should further quantify the benefits of nonsmoking, both for cancer prevention and for improving survival among CRC patients, in particular also in terms of treatment response.
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