Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 535439
Title Fine-scale spatial and temporal variation of clinical malaria incidence and associated factors in children in rural Malawi : A longitudinal study
Author(s) Kabaghe, Alinune N.; Chipeta, Michael G.; Gowelo, Steve; Mburu, Monicah; Truwah, Zinenani; McCann, Robert S.; Vugt, Michèle Van; Grobusch, Martin P.; Phiri, Kamija S.
Source Parasites & Vectors 11 (2018)1. - ISSN 1756-3305
DOI http://dx.doi.org/10.1186/s13071-018-2730-y
Department(s) Laboratory of Entomology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Entomological surveillance - Incidence rate - Malaria - Spatio-temporal heterogeneity
Abstract Background: Spatio-temporal variations in malaria burden are currently complex and costly to measure, but are important for decision-making. We measured the spatio-temporal variation of clinical malaria incidence at a fine scale in a cohort of children under five in an endemic area in rural Chikhwawa, Malawi, determined associated factors, and monitored adult mosquito abundance. Methods: We followed-up 285 children aged 6-48 months with recorded geolocations, who were sampled in a rolling malaria indicator survey, for one year (2015-2016). Guardians were requested to take the children to a nearby health facility whenever ill, where health facility personnel were trained to record malaria test results and temperature on the child's sick-visit card; artemisinin-based combination therapy was provided if indicated. The cards were collected and replaced 2-monthly. Adult mosquitoes were collected from 2-monthly household surveys using a Suna trap. The head/thorax of adult Anopheles females were tested for presence of Plasmodium DNA. Binomial logistic regression and geospatial modelling were performed to determine predictors of and to spatially predict clinical malaria incidence, respectively. Results: Two hundred eighty two children, with complete results, and 267.8 child-years follow-up time were included in the analysis. The incidence rate of clinical malaria was 1.2 cases per child-year at risk; 57.1% of the children had at least one clinical malaria case during follow-up. Geographical groups of households where children experienced repeated malaria infections overlapped with high mosquito densities and high entomological inoculation rate locations. Conclusions: Repeated malaria infections within household groups account for the majority of cases and signify uneven distribution of malaria risk within a small geographical area.
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