Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 535449
Title Functional significance and structure–activity relationship of food-derived α-glucosidase inhibitors
Author(s) Stefano, Elisa Di; Oliviero, Teresa; Udenigwe, Chibuike C.
Source Current Opinion in Food Science 20 (2018). - ISSN 2214-7993 - p. 7 - 12.
Department(s) Food Quality and Design
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract The ageing population, together with unhealthy diets, physical inactivity and obesity are the main drivers of the increased prevalence of Type 2 diabetes mellitus (T2DM). Apart from pharmacological treatments, the food industries can play a significant role in the management of T2DM. One of the main strategies is to reduce the sugar content in food. Moreover, another promising strategy is to design food products with natural ingredients that are capable of inhibiting α-glucosidase during digestion, thereby reducing the rate of glucose release from ingested carbohydrate. Studies report that food-derived phenolic compounds, peptides, terpenoids and non-starch polysaccharides inhibit α-glucosidase activity. This review discusses the structure-function relationship of α-glucosidase inhibitors from food sources, and their potential application in modulating glucose metabolism.
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