Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 535574
Title Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses
Author(s) Wilbers, Ruud H.P.; Westerhof, Lotte B.; Raaij, Debbie R. Van; Bakker, Jaap; Smant, Geert; Schots, Arjen
Source Future Science OA 14 (2018)4. - ISSN 2056-5623
DOI http://dx.doi.org/10.4155/fsoa-2017-0133
Department(s) Laboratory of Nematology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract Aim: Treatment of inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. IL-10 is a cytokine with therapeutic potential, but until now has not been as successful as previously anticipated. A reason for this may be that IL-10 responsiveness depends on the environment of the inflamed tissue. In this study we investigated whether GM-CSF is able to influence IL-10-mediated responses. Methodology: Dendritic cells and macrophages were differentiated from mouse bone marrow and treated or depleted from GM-CSF prior to analyze their response to IL-10. Activity was assessed by measuring cytokine expression upon lipopolysaccharide stimulation, IL-10-induced signaling and downstream gene expression. Conclusion: This study describes that GM-CSF negatively regulates IL-10-mediated responses.
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