Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 535804
Title LPCAT1 controls phosphate homeostasis in a zinc-dependent manner
Author(s) Kisko, Mushtak; Bouain, Nadia; Safi, Alaeddine; Medici, Anna; Akkers, Robert C.; Secco, David; Fouret, Gilles; Krouk, Gabriel; Aarts, Mark G.M.; Busch, Wolfgang; Rouached, Hatem
Source eLife 7 (2018). - ISSN 2050-084X
DOI https://doi.org/10.7554/eLife.32077
Department(s) Groep KoornneefGroep Koornneef
EPS
Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

All living organisms require a variety of essential elements for their basic biological functions. While the homeostasis of nutrients is highly intertwined, the molecular and genetic mechanisms of these dependencies remain poorly understood. Here, we report a discovery of a molecular pathway that controls phosphate (Pi) accumulation in plants under Zn deficiency. Using genome-wide association studies, we first identified allelic variation of the Lyso- Phosphatidyl Choline (PC) Acyl Transferase 1 (LPCAT1) gene as the key determinant of shoot Pi accumulation under Zn deficiency. We then show that regulatory variation at the LPCAT1 locus contributes significantly to this natural variation and we further demonstrate that the regulation of LPCAT1 expression involves bZIP23 TF, for which we identified a new binding site sequence. Finally, we show that in Zn deficient conditions loss of function of LPCAT1 increases the phospholipid Lyso-Phosphatidyl Choline/Phosphatidyl Choline ratio, the expression of the Pi transporter PHT1;1, and that this leads to shoot Pi accumulation.

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