Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 535925
Title Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups : The CODAM and Hoorn Studies
Author(s) Wanders, Anne J.; Alssema, Marjan; Hoon, Sabine E.M. De; Feskens, Edith J.M.; Woudenbergh, G.J. van; Kallen, Carla J. van der; Zock, Peter L.; Refsum, Helga; Drevon, Christian A.; Elshorbagy, Amany; Schalkwijk, Casper G.; Stehouwer, Coen D.A.; Dekker, Jacqueline M.; Greevenbroek, Marleen M.J. van
Source Annals of Nutrition & Metabolism 72 (2018)2. - ISSN 0250-6807 - p. 117 - 125.
DOI https://doi.org/10.1159/000486244
Department(s) Human Nutrition (HNE)
Chair Nutrition and Health over the Lifecourse
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Biomarker - Circulating fatty acids - Dietary fat - Polyunsaturated fat
Abstract Aims: To evaluate whether participant characteristics and way of expressing circulating fatty acids (FA) influence the strengths of associations between self-reported intake and circulating levels of linoleic acid (LA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Methods: Cross-sectional analyses were performed in pooled data from the CODAM (n = 469) and Hoorn (n = 702) studies. Circulating FA were measured by gas liquid chromatography and expressed as proportions (% of total FA) and concentrations (µg/mL). Dietary intakes were calculated from a validated food frequency questionnaire. Effects of participant characteristics on associations between dietary and circulating FA were calculated using interaction analyses. Results: Standardized regression coefficients between dietary FA and proportions of circulating FA (% of total FA) were LA β = 0.28, ALA β = 0.13, EPA β = 0.34, and DHA β = 0.45. Body mass index (BMI), waist circumference, and presence of CVD influenced associations for LA; gender influenced LA, EPA, and DHA; alcohol intake influenced LA and DHA; and glucose tolerance status influenced ALA (p values interaction <0.05). Coefficients for circulating FA as concentrations were LA β = 0.19, ALA β = 0.10, EPA β = 0.31, and DHA β = 0.41. Conclusions: This study suggests that characteristics such as BMI, alcohol intake, and expressing circulating FA as proportions or concentrations, influence associations between dietary and circulating FA.
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