Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536066
Title Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice
Author(s) Kok, Dieuwertje E.G.; Rusli, Fenni; Lugt, Benthe van der; Lute, Carolien; Laghi, Luca; Salvioli, Stefano; Picone, Gianfranco; Franceschi, Claudio; Smidt, Hauke; Vervoort, Jacques; Kampman, Ellen; Müller, Michael; Steegenga, Wilma T.
Source Journal of Nutritional Biochemistry 56 (2018). - ISSN 0955-2863 - p. 152 - 164.
DOI http://dx.doi.org/10.1016/j.jnutbio.2018.01.001
Department(s) Chair Nutrition and Disease
Chair Nutrition Metabolism and Genomics
Microbiological Laboratory
VLAG
WIMEK
Biochemistry
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Availibility Full text available from 2019-03-20
Keyword(s) Aging - Calorie restriction - Colonic health - Gene expression - Gut microbiota - Metabolites
Abstract Diminished colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an effective strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here, we report the effects of lifelong CR on indicators of colonic health in aging C57Bl/6J mice. Compared to an ad libitum control and moderate-fat diet, 30% energy reduction was associated with attenuated immune- and inflammation-related gene expression in the colon. Furthermore, expression of genes involved in lipid metabolism was higher upon CR, which may point towards efficient regulation of energy metabolism. The relative abundance of bacteria considered beneficial to colonic health, such as Bifidobacterium and Lactobacillus, increased in the mice exposed to CR for 28 months as compared to the other diet groups. We found lower plasma levels of interleukin-6 and lower levels of various metabolites, among which are bile acids, in the colonic luminal content of CR-exposed mice as compared to the other diet groups. Switching from CR to an ad libitum moderate-fat diet at old age (24 months) revealed remarkable phenotypic plasticity in terms of gene expression, microbiota composition and metabolite levels, although expression of a subset of genes remained CR-associated. This study demonstrated in a comprehensive way that CR affects indicators of colonic health in aging mice. Our findings provide unique leads for further studies that need to address optimal and feasible strategies for prolonged energy deprivation, which may contribute to healthy aging.
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