Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536201
Title Lifelong calorie restriction and markers of colonic health in aging mice
Author(s) Kok, D.E.G.; Rusli, F.; Lugt, B.M. van der; Lute, C.; Laghi, Luca; Salvioli, Stefano; Picone, Gianfranco; Franceschi, Claudio; Smidt, H.; Vervoort, J.J.M.; Kampman, E.; Müller, Michael; Steegenga, W.T.
Department(s) Chair Nutrition and Disease
Chair Nutrition Metabolism and Genomics
Microbiological Laboratory
VLAG
WIMEK
Biochemistry
EPS
Publication type Dataset
Publication year 2018
Keyword(s) Mus musculus - GSE100701 - PRJNA392687
Abstract Diminishment of colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an efficient strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here we report the effects of lifelong CR on markers of colonic health in aging mice. We show that 30% energy reduction, as compared to a control (C) and moderate-fat (MF) diet, is associated with attenuated immune-related gene expression and lower levels of bile acids in the colon. Pronounced shifts in microbiota composition, together with lowered plasma levels of interleukin 6, in mice exposed to CR are in line with these findings. Furthermore, expression of genes involved in lipid metabolism was higher upon CR as compared to C and MF, pointing towards efficient regulation of energy metabolism. Switching from CR to an ad libitum MF diet at old age revealed remarkable phenotypic plasticity, although expression of a small subset of genes remained CR-associated. This research demonstrates that CR beneficially affects markers of colonic health in aging mice and as such may attenuate the progressive age-related decline in health.
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