Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536223
Title A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening
Author(s) Berg, Rosa van den; Kooijman, Sander; Noordam, Raymond; Ramkisoensing, Ashna; Abreu-Vieira, Gustavo; Tambyrajah, Lauren L.; Dijk, Wieneke; Ruppert, Philip; Mol, Isabel M.; Kramar, Barbara; Caputo, Rosanna; Puig, Laura Sardón; Ruiter, Evelien M. de; Kroon, Jan; Hoekstra, Menno; Sluis, Ronald J. van der; Meijer, Onno C.; Willems van Dijk, Ko; Kerkhof, Linda W.M. van; Christodoulides, Constantinos; Karpe, Fredrik; Gerhart-Hines, Zachary; Kersten, Sander; Meijer, Johanna H.; Coomans, Claudia P.; Heemst, Diana van; Biermasz, Nienke R.; Rensen, Patrick C.N.
Source Cell Reports 22 (2018)13. - ISSN 2211-1247 - p. 3521 - 3533.
DOI https://doi.org/10.1016/j.celrep.2018.03.004
Department(s) Human Nutrition (HNE)
Chair Nutrition Metabolism and Genomics
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) angiopoietin-like 4 - APOE3-Leiden.CETP mice - brown adipose tissue - circadian rhythm - diurnal rhythm - fatty acids - lipoprotein lipase - postprandial lipid response - triglycerides
Abstract Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.
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