Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536364
Title Dietary intake of magnesium or calcium and chemotherapy-induced peripheral neuropathy in colorectal cancer patients
Author(s) Wesselink, Evertine; Winkels, Renate M.; Baar, Harm Van; Geijsen, Anne J.M.R.; Zutphen, Moniek Van; Halteren, Henk K. Van; Hansson, Bibi M.E.; Radema, Sandra A.; Wilt, Johannes H.W. De; Kampman, Ellen; Kok, Dieuwertje E.G.
Source Nutrients 10 (2018)4. - ISSN 2072-6643
Department(s) VLAG
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Calcium - Chemotherapy - Colorectal cancer - Magnesium - Neuropathy - Oxaliplatin
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β-1.08, 95% CI -1.95, -0.22) and after chemotherapy (β-0.93, 95% CI -1.81, -0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
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