Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536410
Title Integrated transcriptomes throughout swine oestrous cycle reveal dynamic changes in reproductive tissues interacting networks
Author(s) Kim, Jun Mo; Park, Jong Eun; Yoo, Inkyu; Han, Jisoo; Kim, Namshin; Lim, Won Jun; Cho, Eun Seok; Choi, Bonghwan; Choi, Sunho; Kim, Tae Hun; Pas, Marinus F.W. Te; Ka, Hakhyun; Lee, Kyung Tai
Source Scientific Reports 8 (2018)1. - ISSN 2045-2322
Department(s) WIAS
LR - Animal Breeding & Genomics
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract Female fertility is a highly regulated process involving the synchronized activities of multiple tissues. The underlying genomic regulation of the tissue synchronization is poorly understood. To understand this better we investigated the transcriptomes of the porcine ovary, endometrium, and oviduct at days 0, 3, 6, 9, 12, 15, or 18 of the oestrous cycle. We analysed the transcriptome profiles of the individual tissues and focus on the bridging genes shared by two or more tissues. The three tissue-networks were connected forming a triangular shape. We identified 65 bridging genes with a high level of connectivity to all other genes in the network. The expression levels showed negative correlations between the ovary and the other two tissues, and low correlations between endometrium and oviduct. The main functional annotations involved biosynthesis of steroid hormones, cell-to-cell adhesion, and cell apoptosis, suggesting that regulation of steroid hormone synthesis and tissue viability are major regulatory mechanisms.
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