Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536468
Title Taste and smell perception and quality of life during and after systemic therapy for breast cancer
Author(s) Vries, Y.C. de; Boesveldt, S.; Kelfkens, C.S.; Posthuma, E.E.; Den Berg, M.M.G.A. van; Kruif, J.T.C.M. de; Haringhuizen, A.; Sommeijer, D.W.; Buist, N.; Grosfeld, S.; Graaf, C. de; Laarhoven, H.W.M. van; Kampman, E.; Winkels, R.M.
Source Breast Cancer Research and Treatment 170 (2018)1. - ISSN 0167-6806 - p. 27 - 34.
DOI http://dx.doi.org/10.1007/s10549-018-4720-3
Department(s) Chair Sensory Science and Eating Behaviour
CS CC&M Voorlichting en WervingCC&M Voorlichting en Werving
Human Nutrition (HNE)
MW F&CF&C
Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Breast cancer - Chemotherapy - Dysgeusia - Herceptin - Quality of life - Smell - Taste - Taste loss - Trastuzumab
Abstract Purpose: The purpose of the study was to assess self-reported taste and smell perception after chemotherapy in breast cancer patients compared with women without cancer, and to assess whether taste and smell perception is associated with quality of life after the end of chemotherapy. Methods: We included 135 newly diagnosed breast cancer patients who completed chemotherapy and 114 women without cancer. Questionnaires on taste, smell, and quality of life were completed shortly after and 6 months after chemotherapy (patients) or at two moments with 6 months’ time window in between (comparisons). Results: Self-reported taste and smell perception were significantly lower in patients shortly after chemotherapy compared to the comparison group. Most patients recovered 6 months after chemotherapy, although patients who were still receiving trastuzumab then reported a lower taste and smell perception compared to patients who were not. A lower self-reported taste and smell were statistically significantly associated with a worse quality of life, social, emotional, and role functioning shortly after chemotherapy. Six months after chemotherapy, taste and smell were statistically significantly associated with quality of life, social and role functioning, but only in patients receiving trastuzumab. Conclusions: Most taste and smell alterations recovered within 6 months after the end of chemotherapy for breast cancer, but not for patients receiving trastuzumab. These results highlight the importance of monitoring taste and smell alterations during and after treatment with chemotherapy and trastuzumab, as they may impact quality of life.
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