Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536519
Title Fusarium riograndense sp. nov., a new species in the Fusarium solani species complex causing fungal rhinosinusitis
Author(s) Dallé Rosa, P.; Ramirez-Castrillon, M.; Valente, P.; Meneghello Fuentefria, A.; Diepeningen, A.D. Van; Goldani, L.Z.
Source Journal de Mycologie Medicale 28 (2018)1. - ISSN 1156-5233 - p. 29 - 35.
DOI https://doi.org/10.1016/j.mycmed.2018.01.004
Department(s) PPO/PRI Biointeractions and Plant Health
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Antifungal susceptibility - Fusarium - MLST - Molecular phylogeny - Morphology
Abstract Invasive fusariosis has a high mortality and is predominantly observed in patients with leukemia. We report the first case of a novel species of Fusarium, Fusarium riograndense sp. nov, isolated from a lesion in the nasal cavity lesion of a patient with acute lymphoblastic leukemia. The etiological agent was identified by Multilocus Sequencing Typing (MLST), including RPB2, TEF-1α, and ITS-LSU sequences, the gold standard technique to identify new species of Fusarium. MLST and phenotypic data strongly supported its inclusion in the F. solani species complex (FSSC). The new species produced a red pigment in the Sabouraud Dextrose Agar similar to other members of the complex. The macroconiodia developed from phialides on multibranched conidiophores which merge to form effuse sporodochia with a basal foot-cell instead of papilla in basal cell shape. The microconidia were ellipsoidal, 0-1-septated, produced from long monophialides. Chlamydospores were produced singly or in pairs. Amphotericin B (MIC 1. μg/mL) was the most active drug, followed by voriconazole (MIC 8. μg/mL). The patient was successfully treated with voriconazole. Our findings indicate another lineage within FSSC capable causing of invasive human infection.
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