Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 536611
Title Detection of titanium particles in human liver and spleen and possible health implications
Author(s) Heringa, M.B.; Peters, R.J.B.; Bleys, R.L.A.W.; Lee, M.K. van der; Tromp, P.C.; Kesteren, P.C.E. van; Eijkeren, J.C.H. van; Undas, A.K.; Oomen, A.G.; Bouwmeester, H.
Source Particle and Fibre Toxicology 15 (2018)1. - ISSN 1743-8977
DOI https://doi.org/10.1186/s12989-018-0251-7
Department(s) RIKILT - Business unit Contaminants & Toxins
VLAG
Sub-department of Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Human liver - Human spleen - Nanoparticle - Quantification - Risk assessment - Sp-ICP-HRMS - Tissue level - Titanium dioxide
Abstract Background: Titanium dioxide (TiO2) is produced at high volumes and applied in many consumer and food products. Recent toxicokinetic modelling indicated the potential of TiO2 to accumulate in human liver and spleen upon daily oral exposure, which is not routinely investigated in chronic animal studies. A health risk from nanosized TiO2 particle consumption could not be excluded then. Results: Here we show the first quantification of both total titanium (Ti) and TiO2 particles in 15 post-mortem human livers and spleens. These low-level analyses were enabled by the use of fully validated (single particle) inductively coupled plasma high resolution mass spectrometry ((sp)ICP-HRMS) detection methods for total Ti and TiO2 particles. The presence of TiO2 in the particles in tissues was confirmed by Scanning Electron Microscopy with energy dispersive X-ray spectrometry. Conclusions: These results prove that TiO2 particles are present in human liver and spleen, with ≥24% of nanosize (< 100 nm). The levels are below the doses regarded as safe in animals, but half are above the dose that is deemed safe for liver damage in humans when taking into account several commonly applied uncertainty factors. With these new and unique human data, we remain with the conclusion that health risks due to oral exposure to TiO2 cannot be excluded.
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