Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 537576
Title New insights into the phylogeny of the TMBIM superfamily across the three of life : Comparative genomics and synteny networks reveal independent evolution of the BI and LFG families in plants
Author(s) Gamboa-Tuz, Samuel D.; Pereira-Santana, Alejandro; Zhao, Tao; Schranz, M.E.; Castano, Enrique; Rodriguez-Zapata, Luis C.
Source Molecular Phylogenetics and Evolution 126 (2018). - ISSN 1055-7903 - p. 266 - 278.
DOI https://doi.org/10.1016/j.ympev.2018.04.032
Department(s) Biosystematics
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Bax inhibitor 1 - Gene family evolution - Lifeguard - Programmed cell death - Synteny network - TMBIM
Abstract The Transmembrane BAX Inhibitor Motif containing (TMBIM) superfamily, divided into BAX Inhibitor (BI) and Lifeguard (LFG) families, comprises a group of cytoprotective cell death regulators conserved in prokaryotes and eukaryotes. However, no research has focused on the evolution of this superfamily in plants. We identified 685 TMBIM proteins in 171 organisms from Archaea, Bacteria, and Eukarya, and provided a phylogenetic overview of the whole TMBIM superfamily. Then, we used orthology and synteny network analyses to further investigate the evolution and expansion of the BI and LFG families in 48 plants from diverse taxa. Plant BI family forms a single monophyletic group; however, monocot BI sequences transposed to another genomic context during evolution. Plant LFG family, which expanded trough whole genome and tandem duplications, is subdivided in LFG I, LFG IIA, and LFG IIB major phylogenetic groups, and retains synteny in angiosperms. Moreover, two orthologous groups (OGs) are shared between bryophytes and seed plants. Other several lineage-specific OGs are present in plants. This work clarifies the phylogenetic classification of the TMBIM superfamily across the three domains of life. Furthermore, it sheds new light on the evolution of the BI and LFG families in plants providing a benchmark for future research.
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