Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 538000
Title Probabilistic dietary risk assessment of triazole and dithiocarbamate fungicides for the Brazilian population
Author(s) Jardim, Andreia Nunes Oliveira; Mello, Denise Carvalho; Brito, Alessandra Page; Voet, Hilko van der; Boon, Polly E.; Caldas, Eloisa Dutra
Source Food and Chemical Toxicology 118 (2018). - ISSN 0278-6915 - p. 317 - 327.
DOI https://doi.org/10.1016/j.fct.2018.05.002
Department(s) Biometris (PPO/PRI)
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Brazil - Cumulative acute and chronic dietary risk assessment - dithiocarbamates - MCRA - triazoles
Abstract

Residue data for triazoles (TR) and dithiocarbamates (DT) in 30,786 samples of 30 foods were obtained from mainly two national monitoring programs, and consumption data from a national survey conducted among persons aged 10 years or older. About 16% of the samples contained TR, mainly grape (53.5%), and 16.2% contained DT, mainly apple (59.3%). Flusilazole was the index compound used for the acute effects of TR for women of child-bearing-age (cranium-facial malformation and skeletal variation), cyproconazole for the chronic effects of TR (hepatoxicity), and ethylene-bis-dithitiocarbamates (EBDC) for DT (thyroid toxicity). Exposures were estimated using the Monte Carlo Risk Assessment software. Different models were tested, and a Model-Then-Add approach was found to best estimate the chronic exposures to DT and TR. At the 99.9th percentile (P99.9), the cumulative acute TR intakes accounted for up to 0.5% of the flusilazole ARfD, mainly from beans and rice consumption. The chronic TR and DT intakes accounted for 1 and 6.7% of the respective index compound ADIs, with beans and rice accounting for most of the TR intake (∼70%), and apple for about 51–56% of the DT intake. The estimated risks from the exposure to TR and DT indicate no health concern for the Brazilian population.

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