Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 538327
Title Distinct substrate specificities and electron-donating systems of fungal lytic polysaccharide monooxygenases
Author(s) Frommhagen, Matthias; Westphal, Adrie H.; Berkel, Willem J.H. van; Kabel, Mirjam A.
Source Frontiers in Microbiology 9 (2018). - ISSN 1664-302X
DOI https://doi.org/10.3389/fmicb.2018.01080
Department(s) Food Chemistry Group
Biochemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) C1/C4-oxidation - Electron donor - Hydrogen peroxide - LPMO - Lytic polysaccharide monooxygenase - Oxygen - Reducing agent - Substrate specificity
Abstract

Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost the degradation of lignocellulose has greatly stimulated research efforts and biocatalytic applications within the biorefinery field. Initially found as oxidizing recalcitrant substrates, such as chitin and cellulose, it is now clear that LPMOs cleave a broad range of oligo- and poly-saccharides and make use of various electron-donating systems. Herein, substrate specificities and electron-donating systems of fungal LPMOs are summarized. A closer look at LPMOs as part of the fungal enzyme machinery might provide insights into their role in fungal growth and plant-pathogen interactions to further stimulate the search for novel LPMO applications.

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