Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 538345
Title High adiposity is associated with higher nocturnal and diurnal glycaemia, but not with glycemic variability in older individuals without diabetes
Author(s) Noordam, Raymond; Huurman, Neline C.; Wijsman, Carolien A.; Akintola, Abimbola A.; Jansen, Steffy W.M.; Stassen, Stephanie; Beekman, Marian; Rest, Ondine van de; Slagboom, P.E.; Mooijaart, Simon P.; Heemst, Diana van
Source Frontiers in Endocrinology 9 (2018).
DOI https://doi.org/10.3389/fendo.2018.00238
Department(s) VLAG
Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Adiposity - Body composition - Continuous glucose monitoring - Glycemia - Glycemic variability
Abstract

Background: It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of glycemic variability over a 72-h period in non-diabetic older adults. Methods: This cross-sectional study was conducted in non-diabetic individuals from the Active and Healthy Aging Study (N = 228), Switchbox (N = 116), and the Growing Old Together Study (N = 94). Body mass index (BMI) and waist circumference were measured, and indices of glycemia and glycemic variability were derived from continuous glucose monitoring (CGM) using the Mini-Med® CGM system. Associations between adiposity and CGM were studied separately for the three cohorts, and derived estimates were subsequently meta-analyzed. Results: After meta-analyzing the results from the separate cohorts, individuals with a higher BMI had higher levels of glycemia. Individuals with BMI between 30 and 35 kg/m2 had 0.28 mmol/L [95% confidence interval (CI): 0.12-0.44] higher 72 h-mean glucose concentration, 0.26 mmol/L (0.10-0.42) higher diurnal glucose (6:00 a.m. to 0:00 a.m.), and 0.39 mmol/L (0.19; 0.59) higher nocturnal glucose (3:00 a.m. to 6:00 a.m.) than participants with a normal weight (BMI 18.5-25 kg/m2). However, no associations were observed between higher BMI and glycemic variability. Results for glycemia and glycemic variability were similarly observed for a high waist circumference. Conclusion: High adiposity associates with constant higher mean glucose levels over the day in non-diabetic older adults.

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