Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 538543
Title The intelligent delivery systems for bioactive compounds in foods : Physicochemical and physiological conditions, absorption mechanisms, obstacles and responsive strategies
Author(s) Chai, Jingjing; Jiang, Ping; Wang, Pengjie; Jiang, Yumeng; Li, Dan; Bao, Weier; Liu, Bingxue; Liu, Bin; Zhao, Liyun; Norde, Willem; Yuan, Qipeng; Ren, Fazheng; Li, Yuan
Source Trends in Food Science and Technology 78 (2018). - ISSN 0924-2244 - p. 144 - 154.
DOI https://doi.org/10.1016/j.tifs.2018.06.003
Department(s) Physical Chemistry and Soft Matter
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Bioaccessibility - Bioactive compounds - Bioavailability - Delivery barriers - Encapsulation - Intelligent delivery systems
Abstract

Background: Bioactive natural compounds have received considerable attention due to their health benefits, including anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing functions. However, the stability of these sensitive compounds can be influenced by unfavourable environmental conditions during processing and storage. In addition, delivery of bioactive compounds via the oral route is restricted by various physiological barriers, including a harsh pH, gastrointestinal enzymes, the mucus layer, and the epithelium. Intelligent delivery systems are a promising method to protect bioactive molecules from degradation and improve their bioavailability. Scope and approach: We have demonstrated the physicochemical and physiological GI conditions. The structural composition of the epithelium and transport mechanisms of bioactives and nanoparticles across the intestinal epithelium were discussed. The effects of enhanced aqueous solubility, stability, bioaccessibility and bioavailability after encapsulation were illustrated. Furthermore, novel intelligent carriers that are responsive to the oral route, pH, enzymes and cell receptors were also discussed. Key findings and conclusions: This comprehensive multidisciplinary review provides useful guidelines for the application of bioactive compounds in the food industry. Intelligent carrier systems are designed to improve the low solubility, poor stability and low permeability of the gastrointestinal tract, and they have the potential to improve oral bioavailability.

Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.