Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 538910
Title Gender and strain dependent differences in intestinal immunology correlate with differences in microbiota composition (colon)
Author(s) Elderman, Marlies; Hugenholtz, F.; Belzer, C.; Boekschoten, M.V.; Beek, A.A. van; Haan, Bart J. de; Savelkoul, H.F.J.; Vos, Paul de; Faas, Marijke M.
Department(s) Microbiological Laboratory
Host Microbe Interactomics
VLAG
Chair Nutrition Metabolism and Genomics
Cell Biology and Immunology
WIAS
Publication type Dataset
Publication year 2018
Keyword(s) Mus musculus - GSE85911 - PRJNA339744
Abstract A dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a gender bias, suggesting gender differences in immune responses and in the intestinal microbiome. We hypothesized that gender differences in immune responses are associated with gender differences in microbiota. We demonstrated mouse strain dependent gender differences in the intestinal microbiome. Interestingly, a cluster of colonic genes (related to humoral and cell-mediated immune responses) correlated oppositely with microbiota species abundant in B6 females and in BALB/c males. This suggests that with different genetic backgrounds, gender associated immune responses are differentially regulated by microbiota. The net result was the same, since both mouse strains showed similar gender induced differences in immune cell populations in the mesenteric lymph nodes. Therefore, host-microbe interactions might be more complicated than assumed, as bacterial-species adaptations might be highly dependent on the genetic make-up of the individual.
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