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Record number 538958
Title Shooting the messenger : RNA-targetting CRISPR-Cas systems
Author(s) Zhu, Yifan; Klompe, Sanne E.; Vlot, Marnix; Oost, John van der; Staals, Raymond H.J.
Source Bioscience Reports 38 (2018)3. - ISSN 0144-8463
DOI https://doi.org/10.1042/BSR20170788
Department(s) Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

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