Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 538976
Title Mycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5) : A Case Series
Author(s) Boral, Hazal; Diepeningen, Anne van; Erdem, Elif; Yağmur, Meltem; Hoog, G.S. de; Ilkit, Macit; Meis, Jacques F.; Al-Hatmi, Abdullah M.S.
Source Mycopathologia 183 (2018)5. - ISSN 0301-486X - p. 835 - 840.
DOI https://doi.org/10.1007/s11046-018-0280-7
Department(s) PPO/PRI Biointeractions and Plant Health
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Amphotericin B - Chlorhexidine gluconate - Keratomycosis - Soft contact lenses - Voriconazole
Abstract

Owing to a lack of appropriate diagnostic and therapeutic approaches for mycotic keratitis, approximately one million cases of preventable corneal blindness are reported each year. The number of keratitis cases due to infection with Fusarium is increasing significantly worldwide, many of which are not treated adequately and in a timely manner due to frequent misdiagnosis. In the current report, we describe three cases of keratitis caused by Fusarium solani sensu stricto (FSSC5) from Turkey and The Netherlands, following ocular trauma. The etiological agent of keratitis, FSSC5, identified by sequencing of the partial tef1-α gene, exhibited low minimum inhibitory concentrations (MICs) of 1 µg/mL for amphotericin B and high MICs above the published epidemiological cutoff values for voriconazole (8 µg/mL). Patients were successfully treated with topical amphotericin B and voriconazole with complete recovery.

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