Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539144
Title Targeting microbial pathogens
Author(s) Thomma, Bart P.H.J.; Cook, David E.
Source Science 360 (2018)6393. - ISSN 0036-8075 - p. 1070 - 1071.
DOI https://doi.org/10.1126/science.aat9343
Department(s) Laboratory of Phytopathology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract One of the most important challenges in agricultural production is to safeguard crops from pathogen infection. Uncovering the molecular mechanisms governing plant-microbe interactions can provide new strategies by which to sustainably intensify agriculture and can additionally contribute to our broader understanding of interspecies interactions (1). On page 1126 of this issue, Cai et al. (2) report that plant hosts secrete extracellular vesicles containing small RNA (sRNA), which are taken up by, and lead to silencing of, fungal virulence–related genes during infection (see the figure). These findings address the previously unknown phenomenon by which host sRNA can alter gene expression in other organisms, highlighting the role of extracellular vesicle–mediated transport as a key element of cross-kingdom RNA interference (RNAi). This could be exploited in the development of RNAi-based pathogen control strategies to protect crops.
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