Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539198
Title Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass
Author(s) Zoon, H.F.A.; Bruijn, S.E.M. de; Jager, G.; Smeets, P.A.M.; Graaf, C. de; Janssen, I.M.C.; Schijns, W.; Deden, L.; Boesveldt, S.
Source Biological Psychology 137 (2018). - ISSN 0301-0511 - p. 34 - 41.
DOI https://doi.org/10.1016/j.biopsycho.2018.06.005
Department(s) Human Nutrition (HNE)
CS CC&M Voorlichting en WervingCC&M Voorlichting en Werving
Chair Sensory Science and Eating Behaviour
VLAG
MW F&CF&C
Publication type Refereed Article in a scientific journal
Publication year 2018
Availibility Full text available from 2019-09-01
Keyword(s) Bariatric surgery - fMRI - Food preferences - go/no-go - Impulsivity - Inhibitory control - Weight-Loss
Abstract

Background: Roux-en-Y gastric bypass (RYGB) surgery is a highly effective weight-loss intervention that often reduces preference and intake of high-energy foods. Research into the neural mechanisms behind this shift has mainly focused on reward processing of food cues. However, the ability to successfully control food intake and thereby weight-loss also depends on inhibitory control capacity. We investigated whether RYGB leads to alterations in neural inhibitory control in response to food cues. Methods: A food-specific go/no-go task with pictures of high-energy (desserts) and low-energy foods (vegetables), was used to assess neural inhibition responses before and after RYGB with functional magnetic resonance imaging. Data from 18 morbidly obese patients (15 females; age 41 ± 11 years; BMI 42 ± 4 kg/m2 before; BMI 36 ± 4 kg/m2 after) were analysed. Pre- and post-RYGB BOLD fMRI responses were compared for response inhibition towards high- and low-energy foods. Participants were tested in a satiated state. Results: Response inhibition to high-energy foods was associated with increased activation of the right lateral prefrontal cortex (PFC), right medial PFC, dorsolateral PFC, right middle cingulate cortex and the right inferior frontal operculum (involved in inhibitory control), after compared to before surgery. Response inhibition to low-energy foods elicited diminished post- compared to pre-surgery responses in the left superior temporal pole, right parahippocampal gyrus and right hypothalamus (involved in metabolic control). Conclusion: Neural changes indicate improved response inhibition towards high-energy food cues, altered influence of metabolic control during response inhibition towards low-energy food cues and a more positive attitude to both high-energy and low-energy food after RYGB. Alterations in neural circuits involved in inhibitory control, satiety signalling and reward processing may contribute to effective weight-loss after RYGB.

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