Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 539375
Title Flux, impact, and fate of halogenated xenobiotic compounds in the gut
Author(s) Atashgahi, Siavash; Shetty, Sudarshan A.; Smidt, Hauke; Vos, Willem M. de
Source Frontiers in Physiology 9 (2018)JUL. - ISSN 1664-042X
DOI https://doi.org/10.3389/fphys.2018.00888
Department(s) Microbiological Laboratory
WIMEK
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Dehalogenation genes - Gut microbiota - Halogenated compounds - Metagenomics - Xenobiotic-microbiota interaction - Xenobiotics
Abstract

Humans and their associated microbiomes are exposed to numerous xenobiotics through drugs, dietary components, personal care products as well as environmental chemicals. Most of the reciprocal interactions between the microbiota and xenobiotics, such as halogenated compounds, occur within the human gut harboring diverse and dense microbial communities. Here, we provide an overview of the flux of halogenated compounds in the environment, and diverse exposure routes of human microbiota to these compounds. Subsequently, we review the impact of halogenated compounds in perturbing the structure and function of gut microbiota and host cells. In turn, cultivation-dependent and metagenomic surveys of dehalogenating genes revealed the potential of the gut microbiota to chemically alter halogenated xenobiotics and impact their fate. Finally, we provide an outlook for future research to draw attention and attract interest to study the bidirectional impact of halogenated and other xenobiotic compounds and the gut microbiota.

Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.