Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539376
Title Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers : Lewis Positive Secretor Subgroups
Author(s) Elwakiel, M.; Hageman, J.A.; Wang, W.; Szeto, I.M.; Goudoever, J.B. van; Hettinga, K.A.; Schols, H.A.
Source Journal of Agricultural and Food Chemistry 66 (2018)27. - ISSN 0021-8561 - p. 7036 - 7043.
DOI https://doi.org/10.1021/acs.jafc.8b02021
Department(s) Food Quality and Design
Food Chemistry Group
Biometris (WU MAT)
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) carbohydrates - genetic polymorphisms - lactation stage - variability
Abstract

To study the variability in human milk oligosaccharide (HMO) composition of Chinese human milk over a 20-wk lactation period, HMO profiles of 30 mothers were analyzed using CE-LIF. This study showed that total HMO concentrations in Chinese human milk decreased significantly over a 20-wk lactation period, independent of the mother's SeLe status, although with individual variations. In addition, total acidic and neutral HMO concentrations in Chinese human milk decreased over lactation, and levels are driven by their mother's SeLe status. Analysis showed that total neutral fucosylated HMO concentrations in Chinese human milk were higher in the two secretor groups as compared to the nonsecretor group. On the basis of the total neutral fucosylated HMO concentrations in Chinese human milk, HMO profiles within the Se+Le+ group can be divided into two subgroups. HMOs that differed in level between Se+Le+ subgroups were 2′FL, DF-L, LNFP I, and F-LNO. HMO profiles in Dutch human milk also showed Se+Le+ subgroup division, with 2′FL, LNT, and F-LNO as the driving force.

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