Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539455
Title Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis
Author(s) Lachmandas, Ekta; Rios-Miguel, Ana B.; Koeken, Valerie A.C.M.; Pasch, Eva van der; Kumar, Vinod; Matzaraki, Vasiliki; Li, Yang; Oosting, Marije; Joosten, Leo A.B.; Notebaart, Richard A.; Noursadeghi, Mahdad; Netea, Mihai G.; Crevel, Reinout van; Pollara, Gabriele
Source The Journal of Infectious Diseases 218 (2018)1. - ISSN 0022-1899 - p. 165 - 170.
DOI https://doi.org/10.1093/infdis/jiy173
Department(s) Food Microbiology Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) cytokines - functional genomics - human challenge model - immune response - immunometabolism - metabolism - microarrays - transcriptomics - tuberculosis
Abstract

Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis. Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine, and inositol phosphate pathways was evident at the site of a human tuberculin skin test challenge in patients with active tuberculosis infection. For 28 metabolic genes, we identified single nucleotide polymorphisms that were trans-acting for in vitro cytokine responses to M. tuberculosis stimulation, including glutathione and pyrimidine metabolism genes that alter production of Th1 and Th17 cytokines. Our findings identify novel therapeutic targets in host metabolism that may shape protective immunity to tuberculosis.

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