Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539602
Title Orthogonal, dual protein labelling by tandem cycloaddition of strained alkenes and alkynes to : Ortho -quinones and azides
Author(s) Bruins, Jorick J.; Blanco-Ania, Daniel; Doef, Vincent van der; Delft, Floris L. van; Albada, Bauke
Source Chemical Communications 54 (2018)53. - ISSN 1359-7345 - p. 7338 - 7341.
DOI https://doi.org/10.1039/c8cc02638f
Department(s) Laboratory for Organic Chemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Reaction of cyclopropanated trans-cyclooctene (cpTCO) with in situ generated ortho-quinone is an efficient tool for bioorthogonal protein conjugation. The (4+2)-cycloaddition of cpTCO with ortho-quinone is significantly faster than its cyclooctyne counterpart (BCN). Orthogonal, tandem cpTCO-quinone and BCN-azide cycloadditions afforded a homogeneous, dual labelled antibody-drug conjugate.

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