Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539638
Title Supplement use and dietary sources of folate, vitamin D, and n-3 fatty acids during preconception : The GLIMP2 study
Author(s) Looman, Moniek; Berg, Claudia van den; Geelen, Anouk; Samlal, Rahul A.K.; Heijligenberg, Rik; Klein Gunnewiek, Jacqueline M.T.; Balvers, Michiel G.J.; Leendertz-Eggen, Caroline L.; Wijnberger, Lia D.E.; Feskens, Edith J.M.; Brouwer-Brolsma, Elske M.
Source Nutrients 10 (2018)8. - ISSN 2072-6643
DOI https://doi.org/10.3390/nu10080962
Department(s) Chair Nutrition and Health over the Lifecourse
Human and Animal Physiology
ATV VlagVlag
Chair Nutrition and Disease
Human Nutrition (HNE)
VLAG
Chair Nutrition and Pharmacology (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Diet - Folate - N-3 fatty acids - Preconception - Supplements - Vitamin D
Abstract

An adequate nutritional status during the preconception period is important, particularly for folate, vitamin D, and n-3 fatty acids (i.e., EPA+DHA). We aimed to determine supplement intake and the main dietary sources of folate, vitamin D, and EPA+DHA using the data of 66 Dutch women aged 18–40 years who wished to become pregnant. Additionally, associations of these intakes with their blood levels were examined. Dietary intake was assessed with a validated food frequency questionnaire, and supplement use with a structured questionnaire. 25-hydroxyvitamin D levels were determined in serum and folate and phospholipid EPA+DHA levels in plasma. Partial Spearman’s correlations, restricted cubic splines and trend analyses over tertiles of nutrient intakes were performed to examine intake-status associations. A large proportion of women did not meet the Dutch recommended intakes of folate (50%), vitamin D (67%), and EPA+DHA (52%). Vegetables were the main contributor to dietary folate intake (25%), oils and fats to dietary vitamin D intake (39%), and fish to dietary EPA+DHA intake (69%). Fourteen percent of the women had an inadequate folate status and 23% an inadequate vitamin D status. Supplemental folate intake, supplemental and dietary vitamin D intake and dietary EPA+DHA intake were significantly associated with their blood levels. In conclusion, even in our highly educated population, a large proportion did not achieve recommended folate, vitamin D and n-3 fatty acid intakes. Promotion of folate and vitamin D supplement use and fish consumption is needed to improve intakes and blood levels of these nutrients in women who wish to become pregnant.

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