Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539648
Title The Sw-5 gene cluster : Tomato breeding and research toward orthotospovirus disease control
Author(s) Oliveira, Athos S. de; Boiteux, Leonardo S.; Kormelink, Richard; Resende, Renato O.
Source Frontiers in Plant Science 9 (2018). - ISSN 1664-462X
DOI https://doi.org/10.3389/fpls.2018.01055
Department(s) Laboratory of Virology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) NB-LRR - NLR - Orthotospovirus - Resistance - Sw-5 - Sw-5b - Tomato
Abstract

The Sw-5 gene cluster encodes protein receptors that are potentially able to recognize microbial products and activate signaling pathways that lead to plant cell immunity. Although there are several Sw-5 homologs in the tomato genome, only one of them, named Sw-5b, has been extensively studied due to its functionality against a wide range of (thrips-transmitted) orthotospoviruses. The Sw-5b gene is a dominant resistance gene originally from a wild Peruvian tomato that has been used in tomato breeding programs aiming to develop cultivars with resistance to these viruses. Here, we provide an overview starting from the first reports of Sw-5 resistance, positional cloning and the sequencing of the Sw-5 gene cluster from resistant tomatoes and the validation of Sw-5b as the functional protein that triggers resistance against orthotospoviruses. Moreover, molecular details of this plant–virus interaction are also described, especially concerning the roles of Sw-5b domains in the sensing of orthotospoviruses and in the signaling cascade leading to resistance and hypersensitive response.

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