Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 539702
Title Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection
Author(s) Cortjens, Bart; Jong, Rineke de; Bonsing, Judith G.; Woensel, Job B.M. Van; Antonis, Adriaan F.G.; Bem, Reinout A.
Source Thorax 73 (2018)6. - ISSN 0040-6376 - p. 578 - 580.
DOI https://doi.org/10.1136/thoraxjnl-2017-210289
Department(s) CVI Virology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) infection control - innate immunity - neutrophil biology - paediatric lung disaese - respiratory infection - viral infection
Abstract

Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction. Viral load in the lower respiratory tract was not different between the two groups. We conclude that NETs form a relevant target for treatment of airway obstruction in severe RSV disease.

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