Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539746
Title Root stem cell niche organizer specification by molecular convergence of PLETHORA and SCARECROW transcription factor modules
Author(s) Shimotohno, Akie; Heidstra, Renze; Blilou, Ikram; Scheres, Ben
Source Genes and Development 32 (2018)15-16. - ISSN 0890-9369 - p. 1085 - 1100.
DOI https://doi.org/10.1101/gad.314096.118
Department(s) EPS
Laboratory of Molecular Biology
Plant Developmental Biology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Arabidopsis - Organizer - PLT-TCP-SCR complexes - Quiescent center - Stem cell niche - WUSCHEL-RELATED HOMEOBOX 5
Abstract

Continuous formation of somatic tissues in plants requires functional stem cell niches where undifferentiated cells are maintained. In Arabidopsis thaliana, PLETHORA (PLT) and SCARECROW (SCR) genes are outputs of apical– basal and radial patterning systems, and both are required for root stem cell specification and maintenance. The WUSCHEL-RELATED HOMEOBOX 5 (WOX5) gene is specifically expressed in and required for functions of a small group of root stem cell organizer cells, also called the quiescent center (QC). PLT and SCR are required for QC function, and their expression overlaps in the QC; however, how they specify the organizer has remained unknown. We show that PLT and SCR genetically and physically interact with plant-specific teosinte-branched cycloidea PCNA (TCP) transcription factors to specify the stem cell niche during embryogenesis and maintain organizer cells post-embryonically. PLT–TCP–SCR complexes converge on PLT-binding sites in the WOX5 promoter to induce expression.

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