Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 539788
Title Diabetes and necrotizing soft tissue infections—A prospective observational cohort study : Statistical analysis plan
Author(s) Rosén, A.; Arnell, P.; Madsen, M.B.; Nedrebø, B.G.; Norrby-Teglund, A.; Hyldegaard, O.; Santos, V.M. dos; Bergey, F.; Saccenti, E.; Skrede, S.
Source Acta Anaesthesiologica Scandinavica 62 (2018)8. - ISSN 0001-5172 - p. 1171 - 1177.
DOI https://doi.org/10.1111/aas.13130
Department(s) Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) critical care - diabetes - INFECT - necrotizing fasciitis - Necrotizing soft tissue infection
Abstract

Background: Necrotizing soft tissue infections (NSTIs) are rare but carry a high morbidity and mortality. The multicenter INFECT project aims to improve the understanding of the pathogenesis, clinical characteristics, diagnosis, and prognosis of NSTIs. This article describes the study outline and statistical analyses that will be used. Methods: Within the framework of INFECT project, patients with NSTI at 5 Scandinavian hospitals are enrolled in a prospective observational cohort study. The goal is to evaluate outcome and characteristics for patients with NSTI and diabetes compared to patients with NSTI without diabetes. The primary outcome is mortality at 90 days after inclusion. Secondary outcomes include days alive and out of ICU and hospital, SAPS II, SOFA score, infectious etiology, amputation, affected body area, and renal replacement therapy. Comparison in mortality between patients with diabetes type 1 and 2 as well as between insulin-treated and non-insulin–treated diabetes patients will be made. Clinical data for diabetic patients with NSTI will be reported. Conclusion: The study will provide important data on patients with NSTI and diabetes.

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