Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 540808
Title MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity
Author(s) Latrasse, David; Jégu, Teddy; Li, H.; Zelicourt, Axel de; Raynaud, Cécile; Legras, Stéphanie; Gust, Andrea; Samajova, Olga; Veluchamy, Alaguraj; Rayapuram, Naganand; Ramirez-Prado, Juan Sebastian; Kulikova, O.; Colcombet, Jean; Genot, Baptiste; Bisseling, A.H.J.; Benhamed, Moussa; Hirt, Heribert
Department(s) Laboratory of Molecular Biology
Publication type Dataset
Publication year 2017
Keyword(s) GSE99936 - Arabidopsis thaliana - PRJNA390146
Abstract Microbial-associated molecular patterns (MAMPs) activate several MAP Kinases (MAPKs), which are major regulators of the innate immune response in Arabidopsis that induce large-scale changes in gene expression. Here, we determined whether MAMP-triggered gene expression involves chromatin modifications at the chromosomal level. Our results show that histone acetylation and deacetylation are major regulators of MAMP-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defense gene expression and innate immunity. The MAPK MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. By studying a number of gene loci that undergo MAMP-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.
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