Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 541071
Title Quantitative analysis of the dose–response of white spot syndrome virus in shrimp
Author(s) Ngo, Thuy T.N.; Senior, Alistair M.; Culina, Antica; Santos, Eduardo S.A.; Vlak, Just M.; Zwart, Mark P.
Source Journal of Fish Diseases (2018). - ISSN 0140-7775
DOI https://doi.org/10.1111/jfd.12877
Department(s) Quantitative Veterinary Epidemiology
Laboratory of Virology
PE&RC
Laboratory of Genetics
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) dose–response - infection - meta-analysis - modelling - shrimp - white spot syndrome virus
Abstract

White spot syndrome virus (WSSV) is an important cause of mortality and economic losses in shrimp farming. Although WSSV-induced mortality is virus dose dependent and WSSV infection does not necessarily lead to mortality, the relationships between virus-particle dose, infection and mortality have not been analysed quantitatively. Here, we explored WSSV dose–response by a combination of experiments, modelling and meta-analysis. We performed dose–response experiments in Penaeus vannamei postlarvae, recorded host mortality and detected WSSV infection. When we fitted infection models to these data, two models—differing in whether they incorporated heterogeneous host susceptibility to the virus or not—were supported for two independent experiments. To determine the generality of these results, we reanalysed published data sets and then performed a meta-analysis. We found that WSSV dose–response kinetics is indeed variable over experiments. We could not clearly identify which specific infection model has the most support by meta-analysis, but we argue that these results also are most concordant with a model incorporating varying levels of heterogeneous host susceptibility to WSSV. We have identified suitable models for analysing WSSV dose–response, which can elucidate the most basic virus–host interactions and help to avoid underestimating WSSV infection at low virus doses.

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