Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 541075
Title Targeting mechanisms of tailed bacteriophages
Author(s) Nobrega, Franklin L.; Vlot, Marnix; Jonge, Patrick A. de; Dreesens, Lisa L.; Beaumont, Hubertus J.E.; Lavigne, Rob; Dutilh, Bas E.; Brouns, Stan J.J.
Source Nature Reviews Microbiology (2018). - ISSN 1740-1526
DOI https://doi.org/10.1038/s41579-018-0070-8
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure–function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages. These new insights and approaches pave the way for the application of phages in medicine and biotechnology and enable deeper understanding of their ecology and evolution.

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