Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 541232
Title Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci
Author(s) Munz, Matthias; Richter, Gesa M.; Loos, Bruno G.; Jepsen, Søren; Divaris, Kimon; Offenbacher, Steven; Teumer, Alexander; Holtfreter, Birte; Kocher, Thomas; Bruckmann, Corinna; Jockel-Schneider, Yvonne; Graetz, Christian; Ahmad, Ilyas; Staufenbiel, Ingmar; Velde, Nathalie Van Der; Uitterlinden, André G.; Groot, Lisette C.P.G.M. De; Wellmann, Jürgen; Berger, Klaus; Krone, Bastian; Hoffmann, Per; Laudes, Matthias; Lieb, Wolfgang; Franke, Andre; Erdmann, Jeanette; Dommisch, Henrik; Schaefer, Arne S.
Source European Journal of Human Genetics (2018). - ISSN 1018-4813
DOI https://doi.org/10.1038/s41431-018-0265-5
Department(s) Chair Nutrition and Health over the Lifecourse
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. It is classified into the widespread moderate form chronic periodontitis (CP) and the rare early-onset and severe phenotype aggressive periodontitis (AgP). These different disease manifestations are thought to share risk alleles and predisposing environmental factors. To obtain novel insights into the shared genetic etiology and the underlying molecular mechanisms of both forms, we performed a two step-wise meta-analysis approach using genome-wide association studies of both phenotypes. Genotypes from imputed genome-wide association studies (GWAS) of AgP and CP comprising 5,095 cases and 9,908 controls of North-West European genetic background were included. Two loci were associated with periodontitis at a genome-wide significance level. They located within the pseudogene MTND1P5 on chromosome 8 (rs16870060-G, P = 3.69 × 10−9, OR = 1.36, 95% CI = [1.23–1.51]) and intronic of the long intergenic non-coding RNA LOC107984137 on chromosome 16, downstream of the gene SHISA9 (rs729876-T, P = 9.77 × 10−9, OR = 1.24, 95% CI = [1.15–1.34]). This study identified novel risk loci of periodontitis, adding to the genetic basis of AgP and CP.
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