Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 541276
Title Antibacterial prenylated stilbenoids from peanut (Arachis hypogaea)
Author(s) Bruijn, Wouter J.C. de; Araya-Cloutier, Carla; Bijlsma, Judith; Swart, Anne de; Sanders, Mark G.; Waard, Pieter de; Gruppen, Harry; Vincken, Jean Paul
Source Phytochemistry letters 28 (2018). - ISSN 1874-3900 - p. 13 - 18.
DOI https://doi.org/10.1016/j.phytol.2018.09.004
Department(s) Food Chemistry Group
VLAG
BioNanoTechnology
Publication type Refereed Article in a scientific journal
Publication year 2018
Availibility Full text available from 2020-12-01
Keyword(s) Antimicrobial - Leguminosae - Natural product - Prenylation - Secondary metabolite - Stilbene
Abstract

Stilbenoids are a class of secondary metabolites with a stilbene backbone that can be produced by peanut (Arachis hypogaea) as defence metabolites. Six monomeric prenylated stilbenoids, including the compound arachidin-6 (4), were isolated from extracts of fungus-elicited peanuts (Arachis hypogaea) using preparative liquid chromatography. Their structures were confirmed by MSn, HRMS and NMR spectroscopy and their antibacterial activity was evaluated against methicillin-resistant Staphylococcus aureus (MRSA). Similarly to other phenolic compounds, prenylated derivatives of stilbenoids were more active than their non-prenylated precursors piceatannol, resveratrol, and pinosylvin. Chiricanine A (6), a chain-prenylated pinosylvin derivative, was the most potent compound tested, with a minimum inhibitory concentration (MIC) of 12.5 μg mL−1. Arachidin-6 (4), a ring-prenylated piceatannol derivative, had moderate potency (MIC 50–75 μg mL−1). In conclusion, prenylated stilbenoids represent a group of potential natural antibacterials which show promising activity against MRSA.

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