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Record number 541425
Title Mechanisms of allergen-specific immunotherapy : Diverse mechanisms of immune tolerance to allergens
Author(s) Głobińska, Anna; Boonpiyathad, Tadech; Satitsuksanoa, Pattraporn; Kleuskens, Mirelle; Veen, Willem van de; Sokolowska, Milena; Akdis, Mübeccel
Source Annals of Allergy, Asthma and Immunology 121 (2018)3. - ISSN 1081-1206 - p. 306 - 312.
DOI https://doi.org/10.1016/j.anai.2018.06.026
Department(s) Cell Biology and Immunology
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Objective: The aim of this review is to provide an overview of the current knowledge on the mechanisms of allergen immunotherapy based on the recent publications and clinical trials. Data sources: PubMed literature review. Study selections: In this review, we focus on diverse mechanisms of AIT and provide an insight into alternative routes of administration. Additionally, we review and discuss the most recent studies investigating potential biomarkers and highlight their role in clinical settings. Results: Successful allergen-specific immunotherapy (AIT) induces the reinstatement of tolerance toward allergens and represents a disease-modifying treatment. In the last decades, substantial progress in understanding the mechanisms of AIT has been achieved. Establishment of long-term clinical tolerance to allergens engages a complex network of interactions, modulating the functions of basophils, mast cells, allergen-specific regulatory T and B cells, and production of specific antibodies. The reduction of symptoms and clinical improvement is achieved by skewing the immune response away from allergic inflammation. Conclusion: Although the complex nature of AIT mechanisms is becoming more clear, the need to discover reliable biomarkers to define patients likely to respond to the treatment is emerging.

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