Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 541434
Title Short lifespans of memory T-cells in bone marrow, blood, and lymph nodes suggest that T-cell memory is maintained by continuous self-renewal of recirculating cells
Author(s) Baliu-Piqué, Mariona; Verheij, Myrddin W.; Drylewicz, Julia; Ravesloot, Lars; Boer, Rob J. de; Koets, Ad; Tesselaar, Kiki; Borghans, José A.M.
Source Frontiers in Immunology 9 (2018)SEP. - ISSN 1664-3224
DOI https://doi.org/10.3389/fimmu.2018.02054
Department(s) CVI Bacteriology and Epidemiology
Resource Ecology
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) Bone marrow - Deuterium - Lifespan - Lymphocyte turnover - Mathematical modeling - Memory T-cells - Stable isotope labeling
Abstract

Memory T-cells are essential to maintain long-term immunological memory. It is widely thought that the bone marrow (BM) plays an important role in the long-term maintenance of memory T-cells. There is controversy however on the longevity and recirculating kinetics of BM memory T-cells. While some have proposed that the BM is a reservoir for long-lived, non-circulating memory T-cells, it has also been suggested to be the preferential site for memory T-cell self-renewal. In this study, we used in vivo deuterium labeling in goats to simultaneously quantify the average turnover rates-and thereby expected lifespans-of memory T-cells from BM, blood and lymph nodes (LN). While the fraction of Ki-67 positive cells, a snapshot marker for recent cell division, was higher in memory T-cells from blood compared to BM and LN, in vivo deuterium labeling revealed no substantial differences in the expected lifespans of memory T-cells between these compartments. Our results support the view that the majority of memory T-cells in the BM are self-renewing as fast as those in the periphery, and are continuously recirculating between the blood, BM, and LN.

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