Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 541488
Title Molecular and Evolutionary Determinants of Bacteriophage Host Range
Author(s) Jonge, Patrick A. de; Nobrega, Franklin L.; Brouns, Stan J.J.; Dutilh, Bas E.
Source Trends in Microbiology (2018). - ISSN 0966-842X - 13 p.
DOI https://doi.org/10.1016/j.tim.2018.08.006
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2018
Keyword(s) bacteriophage - broad-host-range phages - phage therapy - specificity - virus–host interaction
Abstract

The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully infect. Host range, one of the central traits to understand in phages, is determined by a range of molecular interactions between phage and host throughout the infection cycle. While many well studied model phages seem to exhibit a narrow host range, recent ecological and metagenomics studies indicate that phages may have specificities that range from narrow to broad. There is a growing body of studies on the molecular mechanisms that enable phages to infect multiple hosts. These mechanisms, and their evolution, are of considerable importance to understanding phage ecology and the various clinical, industrial, and biotechnological applications of phage. Here we review knowledge of the molecular mechanisms that determine host range, provide a framework defining broad host range in an evolutionary context, and highlight areas for additional research.

Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.