Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 541736
Title Improved crispr-cpf1 genome editing tool
Author(s) Oost, J. van der; Baarlen, P. van; Louwen, Rogier
Source Octrooinummer: WO2017155407, verleend: 2017-09-14.
Department(s) VLAG
Microbiological Laboratory
WIAS
Host Microbe Interactomics
Publication type Patent
Publication year 2017
Abstract The invention relates to a Cpf1-based nuclease complex, wherein the guide RNA sequence is irreversibly crosslinked to the Cpf1 protein. The cross-link may be a covalent binding or a non-covalent binding. Such a complex may be used in delivering constructs to a cell that are capable of gene-editing. Use of this cross-linked complex will result in less off-targeting.
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