Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 542167
Title Transcription factor dosage : more or less sufficient for growth
Author(s) Hofhuis, Hugo F.; Heidstra, Renze
Source Current Opinion in Plant Biology 45 (2018). - ISSN 1369-5266 - p. 50 - 58.
DOI https://doi.org/10.1016/j.pbi.2018.05.008
Department(s) Laboratory of Molecular Biology
Plant Developmental Biology
EPS
Publication type Refereed Article in a scientific journal
Publication year 2018
Abstract

Recent findings highlight three instances in which major aspects of plant development are controlled by dosage-dependent protein levels. In the shoot apical meristem the mobile transcription factor WUS displays an intricate function with respect to target regulation that involves WUS dosage, binding site affinity and protein dimerization. The size of the root meristem is controlled by dosage-dependent PLT protein activity. Recent identification of targets and feedbacks provide new insights and entry into possible mechanisms of dosage read-out. Finally, HD-ZIPIII dosage, enforced by a gradient of mobile miRNAs, presents a relatively unexplored case in the radial patterning of vasculature and ground tissue. We evaluate our current knowledge of these three examples and address molecular mechanisms of dosage translation where possible.

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